Corticosteroid treatment in sarcoidosis

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Corticosteroid treatment in sarcoidosis.

At present there is no curative treatment for sarcoidosis. Immunosuppressive and/or immunomodulatory drugs can, however, be used for controlling the disease. Corticosteroids remain the mainstay of therapy. They function by suppressing the pro-inflammatory cytokines and chemokines that are involved in cell-mediated immune responses and granuloma formation. Only in a select group of patients is i...

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Effects of corticosteroid treatment on pulmonary haemodynamics in patients with sarcoidosis.

Effects of 12 months steroid treatment on pulmonary haemodynamics in 24 patients with pulmonary sarcoidosis, stage II and III, were investigated. All patients had a chest radiograph, lung function tests, and pulmonary haemodynamics (measured at rest and during submaximal exercise) prior to the treatment. Resting pulmonary hypertension was found in 3 patients. In 18 an abnormal increase in pulmo...

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Corticosteroid therapy in pulmonary sarcoidosis: a systematic review.

CONTEXT Corticosteroids are used in pulmonary sarcoidosis to reduce symptoms and minimize long-term damage. Spontaneous recovery is a common feature. Both the decision to initiate therapy and the treatment response may be influenced by disease severity, so trials need to use a randomized controlled design. OBJECTIVE To assess the effect of oral and inhaled corticosteroids on chest radiograph ...

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British Thoracic Society Sarcoidosis study: effects of long term corticosteroid treatment.

BACKGROUND Corticosteroids suppress disease activity in pulmonary sarcoidosis and their use produces symptomatic, radiographic, and functional improvement. There is, however, uncertainty regarding their effects on the overall natural history of the condition and long term benefit is unproven. METHODS Patients with pulmonary radiographic shadowing due to sarcoidosis were recruited in a multice...

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Treatment of a solitary pulmonary sarcoidosis mass by CT-guided direct intralesional injection of corticosteroid.

A case is reported of 38-year-old woman with chest pain attributed to a left lung sarcoidosis mass. The mass failed to diminish and symptoms failed to resolve with systemic corticosteroid therapy. CT-guided direct intralesional transthoracic injection of dexamethasone resulted in resolution of the patient's symptoms and a dramatic reduction in the size of the mass within 2 months.

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ژورنال

عنوان ژورنال: European Respiratory Journal

سال: 2006

ISSN: 0903-1936,1399-3003

DOI: 10.1183/09031936.06.00105805